Author Title Type [ Year(Desc)]
Filters: Author is David E Williams  [Clear All Filters]
2006
Yu Z, Löhr CV, Fischer KA, Louderback MA, Krueger SK, Dashwood RH, et al.. In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res. 2006 ;66(2):755-62.
2011
Crowell SRitger, Amin SG, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, et al.. Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents. Toxicol Appl Pharmacol. 2011 ;257(3):365-76.
2012
Fieber LA, Tanguay RL, Walter RB, Williams DE. Aquatic animal models of human disease: selected papers from the 5th conference. Comp Biochem Physiol C Toxicol Pharmacol. 2012 ;155(1):9-10.
Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, et al.. Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol. 2012 ;264(3):377-86.
Benninghoff AD, Orner GA, Buchner CH, Hendricks JD, Duffy AM, Williams DE. Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicol Sci. 2012 ;125(1):69-78.
Shorey LE, Castro DJ, Baird WM, Siddens LK, Löhr CV, Matzke MM, et al.. Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring. Cancer Lett. 2012 ;317(1):49-55.
Downs CA, Ostrander GK, Rougee L, Rongo T, Knutson S, Williams DE, et al.. The use of cellular diagnostics for identifying sub-lethal stress in reef corals. Ecotoxicology. 2012 ;21(3):768-82.
2013
Larkin A, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, et al.. Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol. 2013 ;267(2):192-9.
Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, et al.. Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane. Toxicol Appl Pharmacol. 2013 ;270(1):60-9.
Crowell SRitger, Sharma AK, Amin SG, Soelberg JJ, Sadler NC, Wright AT, et al.. Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. Toxicol Sci. 2013 ;135(1):48-62.
2014
Crowell SRitger, Hanson-Drury S, Williams DE, Corley RA. In vitro metabolism of benzo[a]pyrene and dibenzo[def,p]chrysene in rodent and human hepatic microsomes. Toxicol Lett. 2014 ;228(1):48-55.
2015
Harper TA, Morré J, Lauer FT, McQuistan TJ, Hummel JM, Burchiel SW, et al.. Analysis of dibenzo[def,p]chrysene-deoxyadenosine adducts in wild-type and cytochrome P450 1b1 knockout mice using stable-isotope dilution UHPLC-MS/MS. Mutat Res Genet Toxicol Environ Mutagen. 2015 ;782:51-6.
Siddens LK, Bunde KL, Harper TA, McQuistan TJ, Löhr CV, Bramer LM, et al.. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol. 2015 ;287(2):149-160.
Larkin A, Williams DE, Kile ML, Baird WM. Developing a smartphone software package for predicting atmospheric pollutant concentrations at mobile locations. Comput J. 2015 ;58(6):1431-1442.
Madeen EP, Corley RA, Crowell SRitger, Turteltaub KW, Ognibene TJ, Malfatti M, et al.. Human in Vivo Pharmacokinetics of [(14)C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Microdosing. Chem Res Toxicol. 2015 ;28(1):126-34.
Tilton SC, Siddens LK, Krueger SK, Larkin A, Löhr CV, Williams DE, et al.. Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential. Toxicol Sci. 2015 ;146(1):135-45.
2016
Teeguarden JG, Tan Y-M, Edwards SW, Leonard JA, Anderson KA, Corley RA, et al.. Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework. Environ Sci Technol. 2016 ;50(9):4579-86.
Teeguarden JG, Tan Y-M, Edwards SW, Leonard JA, Anderson KA, Kile ML, et al.. Expanding on Successful Concepts, Models, and Organization. Environ Sci Technol. 2016 ;50(17):8921-2.
Madeen EP, Ognibene TJ, Corley RA, McQuistan TJ, Henderson MC, Baird WM, et al.. Human Microdosing with Carcinogenic Polycyclic Aromatic Hydrocarbons: In Vivo Pharmacokinetics of Dibenzo[def,p]chrysene and Metabolites by UPLC Accelerator Mass Spectrometry. Chem Res Toxicol. 2016 ;29(10):1641-1650.
2017
Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, et al.. Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice. Mol Carcinog. 2017 ;56(1):163-171.
Madeen EP, Williams DE. Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis. Rev Environ Health. 2017 ;32(1-2):73-81.
2018
Hummel JM, Madeen EP, Siddens LK, Uesugi S, McQuistan TJ, Anderson KA, et al.. Pharmacokinetics of [C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction. Food Chem Toxicol. 2018 ;115:136-147.
2019
Madeen EP, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, et al.. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol. 2019 ;364:97-105.
2021
Monica L Vermillion Maier, Siddens LK, Uesugi S, Choi J, Leonard SW, Pennington JM, Smith JN, et al.. 3,3'-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans. Drug Metab Dispos. 2021 ;49(8):694-705.
Pande P, Madeen EP, Williams DE, Crowell SRitger, Ognibene TJ, Turteltaub KW, et al.. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol. 2021 ;:115830.

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